Reduce memory leaks by managing DOM nodes, using WeakMap for references, and carefully handling async operations. Regularly use profiling tools to identify leaks.

Memory leaks can degrade performance over time, especially in large-scale applications. Here are some advanced methods to prevent and manage memory leaks: 1. Minimize Detached DOM Nodes: When removing elements from the DOM, ensure event listeners are also removed to prevent references that lead to leaks. Consider using libraries or frameworks that handle DOM cleanup automatically. 2. Use WeakMap for Short-Lived References: WeakMap is a good choice for storing references that don’t need to be held indefinitely, such as in closures or caches. It allows garbage collection when objects are no longer in use. 3. Control Long-Running Timers and Intervals: Be cautious with setInterval and other timers, as they keep references alive. Always clear timers when they are no longer needed, especially during component unmounting in frameworks like React. 4. Handle Promises and Async Operations Properly: Unhandled promises or long-running async calls can hold memory unexpectedly. Use cleanup functions and wrap asynchronous calls within try-catch blocks to prevent dangling references. 5. Regularly Profile for Leaks: Use tools like Chrome DevTools or Node.js profiling tools to track memory usage over time. Look for patterns in memory that do not free up after operations complete. Following these practices, you can proactively reduce memory leaks and maintain application performance, especially as your app scales in size and complexity.